Superhumps in Low-Mass X-Ray Binaries

We propose a mechanism for the superhump modulations observed in optical photometry of at least two black hole X-ray transients (SXTs). As in extreme mass-ratio cataclysmic variables (CVs), superhumps are assumed to result from the presence of the 3:1 orbital resonance in the accretion disc. This causes the disc to become non-axisymmetric and precess. However the mechanism for superhump luminosity variations in low mass X-ray binaries (LMXBs) must differ from that in CVs, where it is attributed to a tidally-driven modulation of the disc's viscous dissipation, varying on the beat between the orbital and disc precession period. By contrast in LMXBs, tidal dissipation in the outer accretion disc is negligible: the optical emission is overwhelming dominated by reprocessing of intercepted central X-rays. Thus a different origin for the superhump modulation is required. Recent observations and numerical simulations indicate that in an extreme mass-ratio system the disc area changes on the superhump period. We deduce that the superhumps observed in SXTs arise from a modulation of the reprocessed flux by the changing area. Therefore, unlike the situation in CVs, where the superhump amplitude is inclination-independent, superhumps should be best seen in low-inclination LMXBs, whereas an orbital modulation from the heated face of the secondary star should be more prominent at high inclinations. Modulation at the disc precession period (10s of days) may indicate disc asymmetries such as warping. We comment on the orbital period determinations of LMXBs, and the possibility and significance of possible permanent superhump LMXBs.Comment: 6 pages, 1 encapsulated figure. MNRAS in press; replaced to correct typographical error

Defect-dependent colossal negative thermal expansion in UiO-66(Hf) metal-organic framework

Thermally-densified hafnium terephthalate UiO-66(Hf) is shown to exhibit the strongest isotropic negative thermal expansion (NTE) effect yet reported for a metal-organic framework (MOF). Incorporation of correlated vacancy defects within the framework affects both the extent of thermal densification and the magnitude of NTE observed in the densified product. We thus demonstrate that defect inclusion can be used to tune systematically the physical behaviour of a MOF.Comment: 8 pages, 4 figures, revise

Evolving a 24-hr oscillator in budding yeast

We asked how a new, complex trait evolves by selecting for diurnal oscillations in the budding yeast, Saccharomyces cerevisiae. We expressed yellow fluorescent protein (YFP) from a yeast promoter and selected for a regular alternation between low and high fluorescence over a 24-hr period. This selection produced changes in cell adhesion rather than YFP expression: clonal populations oscillated between single cells and multicellular clumps. The oscillations are not a response to environmental cues and continue for at least three cycles in a constant environment. We identified eight putative causative mutations in one clone and recreated the evolved phenotype in the ancestral strain. The mutated genes lack obvious relationships to each other, but multiple lineages change from the haploid to the diploid pattern of gene expression. We show that a novel, complex phenotype can evolve by small sets of mutations in genes whose molecular functions appear to be unrelated to each other. DOI: http://dx.doi.org/10.7554/eLife.04875.00

Mitochondrial function at extreme high altitude.

At high altitude, barometric pressure falls and with it inspired P(O2), potentially compromising O2 delivery to the tissues. With sufficient acclimatisation, the erythropoietic response increases red cell mass such that arterial O2 content (C(aO2)) is restored; however arterial P(O2)(P(aO2)) remains low, and the diffusion of O2 from capillary to mitochondrion is impaired. Mitochondrial respiration and aerobic capacity are thus limited, whilst reactive oxygen species (ROS) production increases. Restoration of P(aO2) with supplementary O2 does not fully restore aerobic capacity in acclimatised individuals, possibly indicating a peripheral impairment. With prolonged exposure to extreme high altitude (>5500 m), muscle mitochondrial volume density falls, with a particular loss of the subsarcolemmal population. It is not clear whether this represents acclimatisation or deterioration, but it does appear to be regulated, with levels of the mitochondrial biogenesis factor PGC-1α falling, and shows similarities to adapted Tibetan highlanders. Qualitative changes in mitochondrial function also occur, and do so at more moderate high altitudes with shorter periods of exposure. Electron transport chain complexes are downregulated, possibly mitigating the increase in ROS production. Fatty acid oxidation capacity is decreased and there may be improvements in biochemical coupling at the mitochondrial inner membrane that enhance O2 efficiency. Creatine kinase expression falls, possibly impairing high-energy phosphate transfer from the mitochondria to myofibrils. In climbers returning from the summit of Everest, cardiac energetic reserve (phosphocreatine/ATP) falls, but skeletal muscle energetics are well preserved, possibly supporting the notion that mitochondrial remodelling is a core feature of acclimatisation to extreme high altitude.Dr Murray thanks the Research Councils UK for supporting his Academic Fellowship, and the British Heart Foundation, BBSRC, Action Medical Research, Isaac Newton Trust and Oroboros Instruments for supporting research in his laboratory. Mr Horscroft thanks the BBSRC for funding his PhD Studentship.This is the author accepted manuscript. The final version is available from Wiley via http://dx.doi.org/10.1113/JP27007

Skeletal muscle energy metabolism in environmental hypoxia: climbing towards consensus.

Skeletal muscle undergoes metabolic remodelling in response to environmental hypoxia, yet aspects of this process remain controversial. Broadly, environmental hypoxia has been suggested to induce: (i) a loss of mitochondrial density; (ii) a substrate switch away from fatty acids and towards other substrates such as glucose, amino acids and ketone bodies; and (iii) a shift from aerobic to anaerobic metabolism. There remains a lack of a consensus in these areas, most likely as a consequence of the variations in degree and duration of hypoxic exposure, as well as the broad range of experimental parameters used as markers of metabolic processes. To attempt to resolve some of the controversies, we performed a comprehensive review of the literature pertaining to hypoxia-induced changes in skeletal muscle energy metabolism. We found evidence that mass-specific mitochondrial function is decreased prior to mass-specific mitochondrial density, implicating intra-mitochondrial changes in the response to environmental hypoxia. This loss of oxidative capacity does not appear to be matched by a loss of glycolytic capacity, which on the whole is not altered by environmental hypoxia. Environmental hypoxia does however induce a selective attenuation of fatty acid oxidation, whilst glucose uptake is maintained or increased, perhaps to support glycolysis in the face of a downregulation of oxidative metabolism, optimising the pathways of ATP synthesis for the hypoxic environment.JAH receives a PhD studentship from the BBSRC. AJM thanks the Research Councils UK for supporting his academic fellowship and Action Medical Research, the British Heart Foundation and the BBSRC for supporting research projects in his laboratory.This is the final version of the article. It first appeared from BioMed Central via http://dx.doi.org/10.1186/2046-7648-3-19

Instability and finite-amplitude self-organization of large-scale coastline shapes

Author Posting. © The Author(s), 2012. This is the author's version of the work. It is posted here by permission of The Royal Society for personal use, not for redistribution. The definitive version was published in Philosophical Transactions of the Royal Society of London Series A-Mathematical Physical and Engineering Sciences 371 (2013):20120363, doi:10.1098/rsta.2012.0363.Recent research addresses the formation of patterns on sandy coastlines on alongshore scales that are large compared with the cross-shore extent of active sediment transport. A simple morphodynamic instability arises from the feedback between wave-driven alongshore sediment flux and coastline shape. Coastline segments with different orientations experience different alongshore sediment fluxes, so that curvatures in coastline shape drive gradients in sediment flux, which can augment the shoreline curvatures. In a simple numerical model, this instability, and subsequent finite-amplitude interactions between pattern elements, lead to a wide range of different rhythmic shapes and behaviours—ranging from symmetric cuspate capes and bays to alongshore migrating ‘flying spits’—depending on the characteristics of the input wave forcing. The scale of the pattern coarsens in some cases because of the merger of migrating coastline features, and in other cases because of non-local screening interactions between coastline protrusions, which affect the waves reaching other parts of the coastline. Features growing on opposite sides of an enclosed water body mutually affect the waves reaching each other in ways that lead to the segmentation of elongated water bodies. Initial tests of model predictions and comparison with observations suggest that modes of pattern formation in the model are relevant in nature

A Closed-Form Solution for the Similarity Transformation Parameters of Two Planar Point Sets

Image registration covers the set of techniques used in matching images of the same scene. A subset of the image registration problem, identifying the parameters in a similarity transformation, has emerged as useful in a recently defined area of machine design: designing mechanisms for rigidbody shape-change. First, this brief paper shows a potential use for image registration techniques outside the field of machine vision. Second, it presents a closed-form solution for the similarity transformation parameters when the point sets to be matched are restricted to two-dimensional space as is needed in the aforementioned design problem